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Updated: Apr 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Prognostic significance of persistent restrictive filling pattern after cardiac resynchronization therapy

Masayoshi Yamamoto1, Yoshihiro Seo, Tomoko Ishizu

  • 1Cardiovascular Division, Faculty of Clinical Medicine, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Journal of Echocardiography
|July 18, 2015
PubMed

Insights

Persistent restrictive filling pattern (RFP) after cardiac resynchronization therapy (CRT) predicts poor outcomes in heart failure patients. Intensive therapy for RFP patients is recommended to improve prognosis.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Medical Device Technology

Background:

  • Cardiac resynchronization therapy (CRT) can improve both systolic and diastolic left ventricular (LV) dysfunction.
  • Diastolic dysfunction significantly impacts heart failure prognosis.
  • The study investigates CRT's effect on diastolic function and patient outcomes.

Purpose of the Study:

  • To assess the impact of CRT on left ventricular diastolic function.
  • To determine the prognostic value of diastolic function patterns after CRT.
  • To identify patient subgroups that may benefit from intensified therapy.

Main Methods:

  • 67 heart failure patients undergoing CRT had LV diastolic function assessed via pulsed Doppler transmitral flow.
  • Patients were classified into restrictive filling pattern (RFP) and non-RFP groups post-CRT.
  • Major adverse cardiovascular events (MACE) and volume response (LV end-systolic volume reduction >15%) were tracked.

Main Results:

  • Persistent RFP one week post-CRT independently predicted MACE, regardless of baseline factors.
  • Volume responders demonstrated significantly better prognosis than non-responders.
  • The worst prognosis was seen in RFP non-responders, while non-RFP responders had the best outcomes.

Conclusions:

  • Persistent restrictive filling pattern after CRT is a strong predictor of poor prognosis.
  • Patients with persistent RFP may require more intensive treatment strategies.
  • Optimizing diastolic function post-CRT is crucial for improving heart failure patient outcomes.
Abstract

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