Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optimization of biological sulfuric acid generation by Acidithiobacillus thiooxidans in a stirred-tank reactor system.

Applied microbiology and biotechnology·2026

Same author

Enzymatic synthesis of bio-based polyesters derived from vanillin.

Frontiers in chemistry·2026

Same author

Tuning casein coagulation and structure: Exploring the effects of ionic strength and glycerol.

International journal of biological macromolecules·2025

Same author

The significance of hydrolase cascades on poly(aspartic) acid biodegradation assessment.

Chemosphere·2025

Same author

Diving into commercial cellulase formulations for circular polyester/cotton separation through targeted depolymerization of cotton.

Frontiers in bioengineering and biotechnology·2025

Same author

Phage display screening for highly specific nickel- and cobalt-binding peptides for bio-recovery of metals.

Waste management (New York, N.Y.)·2025

Same journal

Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay.

Expert review of molecular diagnostics·2026

Same journal

Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung cancer.

Expert review of molecular diagnostics·2026

Same journal

Explainable epigenetic aging clocks: an overview of existing AI models and approaches.

Expert review of molecular diagnostics·2026

Same journal

Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.

Expert review of molecular diagnostics·2026

Same journal

Diagnostics and novel laboratory approaches to combat <i>Neisseria gonorrhoeae</i> antimicrobial resistance.

Expert review of molecular diagnostics·2026

Same journal

Fluid biomarkers in cerebral amyloid angiopathy: current limitations and future directions.

Expert review of molecular diagnostics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 6, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Enzyme-responsive polymers for microbial infection detection.

Doris Schiffer¹, Gregor Tegl, Andrea Heinzle

¹a 1 Austrian Centre of Industrial Biotechnology, Konrad Lorenz Straße 20, 3430 Tulln an der Donau, Austria.

Expert Review of Molecular Diagnostics

|July 18, 2015

Summary

This summary is machine-generated.

Polymer-based diagnostics offer rapid, point-of-care detection of early infections by responding to enzymes. This enables timely treatment adjustments, improving patient outcomes and preventing severe complications.

Keywords:

cathepsin G diagnosis elastase enzyme-responsive polymers gelatinase hydrogel infection lysozyme peptidoglycan platelet concentrate

More Related Videos

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Related Experiment Videos

Last Updated: Apr 6, 2026

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

High-throughput Identification of Bacteria Repellent Polymers for Medical Devices

Published on: November 5, 2016

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

Biomaterials Science
Diagnostic Technologies
Infectious Disease Research

Background:

Current infection detection methods are slow and laboratory-based, hindering timely clinical intervention.
Early detection of infections is crucial for effective treatment and preventing complications.
Polymer-responsive materials offer a potential solution for rapid diagnostics.

Purpose of the Study:

To explore the use of polymers for early-stage infection detection at the point-of-care.
To develop sensitive polymer-based diagnostic tools for identifying microbial or host-derived enzymes.
To enable real-time monitoring of infections in clinical settings.

Main Methods:

Utilizing protein, polysaccharide, and mixed polymer systems designed to react with specific enzymes.
Inducing colorimetric or dye-release responses upon enzyme detection.
Fabricating polymers into formats suitable for point-of-care diagnostic devices.

Main Results:

Demonstrated sensitive detection of low enzyme levels (proteases, glycosyl hydrolases) indicative of early infection.
Achieved real-time responses, contrasting with conventional slow laboratory methods.
Showcased the potential for direct application in diagnostic devices for wound infections and medical device contamination.

Conclusions:

Polymer-based materials provide a sensitive and rapid platform for point-of-care infection diagnostics.
These materials facilitate early detection by responding to infection-specific enzymes.
The developed diagnostic approach allows for timely therapeutic adjustments, improving patient care.