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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Draft Genome Sequence of a Fluconazole-Resistant Candida auris Strain from a Candidemia Patient in India
Cheshta Sharma1, Nitin Kumar2, Jacques F Meis
1Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Abstract:
Candida auris is a multidrug-resistant yeast incriminated in a wide spectrum of invasive infections, especially in intensive care settings. The first draft genome sequence of C. auris, VPCI 479/P/13, from a case with fungemia was sequenced using the Illumina MiSeq platform. The estimated genome size is 12.3 Mb, with 6,675 coding sequences.
Insights
The first draft genome sequence of the multidrug-resistant yeast Candida auris was determined. This provides a crucial resource for understanding and combating its invasive infections, particularly in intensive care units.
Area of Science:
- Microbiology
- Genomics
- Infectious Diseases
Background:
- Candida auris is a multidrug-resistant yeast causing invasive infections, especially in intensive care settings.
- Understanding the genetic makeup of C. auris is critical for developing effective treatments.
Purpose of the Study:
- To determine the first draft genome sequence of Candida auris (VPCI 479/P/13) from a fungemia case.
Main Methods:
- Whole-genome sequencing was performed using the Illumina MiSeq platform.
- Bioinformatic analysis was conducted to assemble the genome and identify coding sequences.
Main Results:
- The estimated genome size of C. auris VPCI 479/P/13 is 12.3 Mb.
- The genome contains 6,675 predicted coding sequences.
Conclusions:
- The availability of the C. auris genome sequence provides a foundation for further research into its virulence and drug resistance mechanisms.
- This genomic data will aid in the development of diagnostic and therapeutic strategies against C. auris infections.
