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Imaging Studies VII: Vascular Imaging01:19

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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Recent Advances in Higher-Order, Multimodal, Biomedical Imaging Agents.

James Rieffel1, Upendra Chitgupi1, Jonathan F Lovell1

  • 1Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, USA.

Small (Weinheim an Der Bergstrasse, Germany)
|July 18, 2015
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Researchers are developing advanced multimodal imaging agents for better diagnostics. These novel nanoparticle contrast agents combine multiple imaging modalities for enhanced preclinical studies.

Keywords:
contrast agentsmedical imagingmultimodalnanoparticles

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Area of Science:

  • Biomedical Imaging
  • Nanotechnology
  • Materials Science

Background:

  • Integrated multimodal scanners usually offer two simultaneous imaging modes.
  • Higher-order multimodality aims to improve diagnostics and guidance using complementary co-registered images.
  • Synergies from combined modalities aid in tracking physiological events and treatment efficacy.

Purpose of the Study:

  • To review recent progress in higher-order multimodal imaging agents.
  • To explore diverse material and structural classes of these agents.
  • To demonstrate their utility in three or more imaging modalities.

Main Methods:

  • Review of preclinical studies on hypermodal contrast agents.
  • Focus on nanoparticulate agents integrating multiple imaging modalities.
  • Analysis of agents with components active for magnetic resonance imaging.

Main Results:

  • Higher-order multimodal agents are increasingly reported in preclinical studies.
  • These agents are typically nanoparticulate due to chemical integration requirements.
  • The majority of reported nanoparticles include magnetic resonance-active components.

Conclusions:

  • Higher-order multimodal imaging agents offer significant potential for advanced diagnostics.
  • Nanoparticulate agents are a promising platform for integrating multiple imaging modalities.
  • Continued research is advancing the development and application of these agents in preclinical settings.