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Related Experiment Video

Updated: Apr 6, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue virus pirates human platelets.

Matthew T Rondina¹, Andrew S Weyrich²

¹UNIVERSITY OF UTAH; GEORGE E. WAHLEN DEPARTMENT OF VETERANS AFFAIRS MEDICAL CENTER.

|July 18, 2015

Summary

This summary is machine-generated.

Dengue virus (DENV) invades human platelets, hijacking their protein-making machinery to multiply. This study offers the first evidence of DENV replication within platelets.

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Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

Area of Science:

Virology
Hematology
Molecular Biology

Background:

Dengue virus (DENV) infection is a significant global health concern.
Platelets play a crucial role in hemostasis and immune responses.
The precise mechanisms of DENV replication and its interaction with host cells are not fully understood.

Purpose of the Study:

To investigate whether dengue virus (DENV) utilizes platelets for replication.
To determine if DENV can hijack the translational machinery of platelets.

Main Methods:

The study employed cell culture models and molecular biology techniques.
Researchers analyzed viral RNA and protein synthesis within isolated human platelets.

Main Results:

The findings demonstrate that dengue virus (DENV) actively replicates within human platelets.
Evidence shows DENV commandeers the platelet's translational machinery to produce viral components.
Infectious virus particles were successfully produced from DENV-infected platelets.

Conclusions:

This research provides the first definitive proof that dengue virus (DENV) infects and replicates in platelets.
Platelets serve as a novel cellular reservoir for DENV replication.
These findings have significant implications for understanding DENV pathogenesis and transmission.