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Our Fat Future: Translating Adipose Stem Cell Therapy.

Rachel C Nordberg1, Elizabeth G Loboa2

  • 1Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, and University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA; Department of Materials Science and Engineering, North Carolina State University, Raleigh, North Carolina, USA.

Stem Cells Translational Medicine
|July 18, 2015
PubMed
Summary
This summary is machine-generated.

Human adipose stem cells (hASCs) show promise for treating various conditions. Advances in research, regulation, and industry are paving the way for widespread clinical use of this potent stem cell therapy.

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Area of Science:

  • Regenerative Medicine
  • Translational Science

Background:

  • Human adipose stem cells (hASCs) possess therapeutic potential for diverse clinical applications.
  • Recent progress in translational research, regulatory frameworks, and industry has advanced hASC therapy towards clinical adoption.

Purpose of the Study:

  • To review advancements in human adipose stem cell therapy.
  • To discuss challenges and progress in translating hASC therapy into mainstream clinical practice.

Main Methods:

  • The review synthesizes information from translational research, regulatory policy, and industrial developments.
  • Key themes in translational technology for hASCs are analyzed, including automation, biosensors, biomimetics, and rapid manufacturing.

Main Results:

  • Significant progress has been made in automated closed-system operations, biosensors, biomimetics, and rapid manufacturing for hASC applications.
  • Current FDA guidance and regulatory considerations for adipose stem cell therapy are examined.
  • An overview of ongoing clinical trials and the burgeoning industry surrounding hASCs is provided.

Conclusions:

  • Human adipose stem cell therapy is nearing mainstream clinical use due to advancements in translational technology, regulatory clarity, and industrial growth.
  • Further research in translational adipose stem cell science is encouraged to overcome remaining challenges and maximize therapeutic potential.