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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
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Community-Acquired Pyelonephritis in Pregnancy Caused by KPC-Producing Klebsiella pneumoniae

Asma Khatri1, Nina Naeger Murphy2, Peter Wiest3

  • 1MetroHealth Medical Center, Cleveland, Ohio, USA University Hospitals Case Medical Center, Cleveland, Ohio, USA.

Antimicrobial Agents and Chemotherapy
|July 18, 2015
PubMed

Insights

Carbapenem-resistant Enterobacteriaceae (CRE) pose a significant challenge in treating common infections during pregnancy. This case highlights the potential risks to both maternal and neonatal health from these difficult-to-treat bacteria.

Area of Science:

  • Infectious Diseases
  • Obstetrics & Gynecology
  • Microbiology

Background:

  • Carbapenem-resistant Enterobacteriaceae (CRE) are a growing public health concern, often associated with severe illness in vulnerable populations.
  • Community-acquired pyelonephritis in pregnancy typically requires prompt antibiotic management.
  • Klebsiella pneumoniae carbapenemase (KPC)-producing strains represent a critical subset of CRE.

Observation:

  • A pregnant patient presented with community-acquired pyelonephritis.
  • The infection was caused by KPC-producing Klebsiella pneumoniae.
  • Despite appropriate antibiotic therapy, the patient experienced prolonged rupture of membranes.

Findings:

  • This case illustrates the difficulty in treating common infections like pyelonephritis caused by CRE in pregnant individuals.
  • Successful delivery of a healthy infant was achieved despite the challenging clinical scenario.
  • The management of CRE infections in obstetric patients requires careful consideration.

Implications:

  • CRE infections present unique challenges in obstetric care, potentially impacting maternal and fetal outcomes.
  • Effective treatment strategies for CRE in pregnant patients are crucial to prevent adverse outcomes.
  • Further research is needed to optimize the management of CRE infections in pregnancy.

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