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Updated: Apr 6, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Pathological and radiological correlation in an autopsy case of combined pulmonary fibrosis and emphysema
Hiroki Karata1, Tomonori Tanaka1, Ryoko Egashira2
1Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Abstract:
We report an educational autopsy case of combined pulmonary fibrosis and emphysema. Radiological patterns of the upper lung were considered as mostly emphysema, but pathological observation revealed significant interstitial fibrosis of usual interstitial pneumonia as a major pathology. The patient eventually developed acute exacerbation of background interstitial pneumonia. Careful radiological and pathological correlation of the current case indicates that regions with distal acinar emphysema on computed tomography image may possess histologically marked dense fibrosis of lethal interstitial pneumonia.
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