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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Crossing Over01:34

Crossing Over

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Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Cleavage and Blastulation01:33

Cleavage and Blastulation

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Related Experiment Video

Updated: Apr 6, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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Embryonic-maternal cross-talk via exosomes: potential implications.

Islam M Saadeldin1, Hyun Ju Oh2, Byeong Chun Lee3

  • 1Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Stem Cells and Cloning : Advances and Applications
|July 18, 2015
PubMed
Summary

Embryonic-maternal cross-talk in reproduction relies on exosomes, which are tiny vesicles carrying crucial molecular cargo. Understanding these nanovesicles opens doors for new reproductive diagnostics and therapies.

Keywords:
embryoendometriummRNAmiRNAplacenta

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Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes
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Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
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Transfer of Mammary Gland-forming Ability Between Mammary Basal Epithelial Cells and Mammary Luminal Cells via Extracellular Vesicles/Exosomes
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Isolation and Profiling of MicroRNA-containing Exosomes from Human Bile
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Area of Science:

  • Reproductive Biology
  • Cellular Communication
  • Nanotechnology

Background:

  • Reproductive tract microenvironments involve complex bidirectional communication.
  • Embryonic-maternal interactions are crucial for successful reproduction.
  • Exosomes act as key mediators in this intricate dialogue.

Purpose of the Study:

  • To review the role of exosomes in embryonic-maternal cross-talk.
  • To highlight the molecular cargo and effects of exosomes.
  • To explore the therapeutic and diagnostic potential of understanding this communication.

Main Methods:

  • Mini-review of existing literature on exosomes in reproduction.
  • Analysis of exosome biogenesis and secretion from reproductive tissues.
  • Examination of exosome cargo (proteins, mRNA, microRNA, DNA).

Main Results:

  • Exosomes are secreted by pre-implantation embryos, oviduct, endometrium, and placenta.
  • These nanovesicles contain diverse molecular cargoes.
  • Exosomes exert significant effects on both embryonic and maternal reproductive environments.

Conclusions:

  • Exosomes are vital communicators in reproductive tract cross-talk.
  • Understanding exosome-mediated mechanisms can lead to novel reproductive regulators.
  • Potential applications include diagnostics and therapeutics for reproductive functions.