Sequential occurrence of immune pancytopenia and de novo DIC in a child with polyclonal immunoblastosis

We report a child with polyclonal immunoblastosis associated with several hematological complications. Pure red cell aplasia (IgG-mediated inhibition of erythropoiesis), immune thrombocytopenia and immune neutropenia with myeloid hypoplasia developed sequentially. In addition, disseminated intravascular coagulation occurred shortly after the administration of prednisolone with rapid shrinkage of hepatosplenomegaly and lymphadenopathy.