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Serum hepcidin concentrations and type 2 diabetes
Alex Aregbesola1, Sari Voutilainen1, Jyrki K Virtanen1
1Alex Aregbesola, Sari Voutilainen, Jyrki K Virtanen, Adeola Aregbesola, Tomi-Pekka Tuomainen, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Yliopistonranta 1C, FI70211 Kuopio, Finland.
World Journal of Diabetes
|July 18, 2015
Summary
Hepcidin, a key iron-regulating hormone, may play a role in type 2 diabetes (T2D) development. Current research is inconclusive, but exploring hepcidin
Area of Science:
- Endocrinology
- Metabolic Diseases
- Iron Metabolism
Background:
- Hepcidin is a peptide hormone crucial for maintaining iron homeostasis.
- Excess body iron stores are linked to type 2 diabetes (T2D).
- The role of hepcidin in T2D aetiopathogenesis is under investigation.
Purpose of the Study:
- To review existing evidence on the potential links between hepcidin and T2D.
- To explore proposed molecular and genetic pathways connecting hepcidin to T2D.
Main Methods:
- Review of human and animal studies at molecular and genetic levels.
- Analysis of epidemiological data.
- Examination of proposed pathways involving STAT3, ferroportin 1, transmembrane protease 6, and inflammatory cytokines (IL-1, IL-6, TNF-α, IL-10).
Main Results:
- Evidence suggests a possible association between hepcidin and T2D.
- Several pathways, including insulin resistance, are implicated.
- Current findings from molecular, genetic, and epidemiological studies are inconclusive.
Conclusions:
- More research is required to confirm or refute hepcidin's role in T2D development.
- Investigating hepcidin's role could provide insights into iron's contribution to T2D aetiopathogenesis.
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