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Topiramate-induced nephrolithiasis

Eleni Z Giannopoulou1, Ludwig Gortner1, Sylvia Peterlini1

  • 1Department of Pediatrics and Neonatology, University Hospital of Saarland Homburg, Saarland, Germany.

Clinical Case Reports
|July 18, 2015
PubMed

Insights

Topiramate, an antiepileptic drug, can cause kidney stones (nephrolithiasis) in children. Regular kidney ultrasounds are advised for pediatric patients taking topiramate to monitor for this rare side effect.

Area of Science:

  • Pediatric Nephrology
  • Clinical Pharmacology
  • Antiepileptic Drug Research

Background:

  • Nephrolithiasis is a known, albeit uncommon, adverse effect associated with topiramate use.
  • Topiramate is a widely prescribed antiepileptic medication with a diverse side effect profile.

Purpose of the Study:

  • To report a case of pediatric nephrolithiasis secondary to topiramate treatment.
  • To highlight the importance of monitoring for renal complications in children using topiramate.

Main Methods:

  • Case report of a 3-year-old male presenting with abdominal pain.
  • Diagnostic workup including imaging to identify renal calcification.

Main Results:

  • A large calcification was identified in the left kidney of the pediatric patient.
  • The patient's presentation was attributed to topiramate-induced nephrolithiasis.

Conclusions:

  • Topiramate should be considered as a potential cause of nephrolithiasis in pediatric patients.
  • Routine renal ultrasound surveillance is recommended for children undergoing topiramate therapy to detect early signs of kidney stone formation.

Keywords:
Abdominal paincalcificationepilepsy

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