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Gallbladder Agenesis with Refractory Choledocholithiasis.

Jamie Tjaden¹, Kevin Patel¹, Aziz Aadam¹

¹Rush University Medical Center, Chicago, IL 60612, USA.

Case Reports in Gastrointestinal Medicine

|July 18, 2015

Summary

This summary is machine-generated.

Congenital agenesis of the gallbladder, a rare condition, can cause symptoms like jaundice and pain due to gallstones. This case highlights the risk of developing new gallstones (de novo choledocholithiasis) in patients with this anomaly.

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Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

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Published on: November 25, 2025

Area of Science:

Gastroenterology and Hepatology
Surgical Pathology

Background:

Congenital agenesis of the gallbladder is a rare congenital anomaly.
While often asymptomatic, it can present with symptoms such as right upper quadrant pain, nausea, vomiting, and jaundice.

Purpose of the Study:

To report a case of symptomatic congenital agenesis of the gallbladder.
To highlight the association with de novo choledocholithiasis and management challenges.

Main Methods:

Case presentation of a 63-year-old female with jaundice and abdominal pain.
Diagnostic workup included elevated liver enzymes, upper endoscopic ultrasound (EUS), and multiple endoscopic retrograde cholangiopancreatography (ERCP) sessions.
Surgical exploration confirmed congenital agenesis of the gallbladder.

Main Results:

The patient presented with jaundice, elevated bilirubin and alkaline phosphatase, and choledocholithiasis.
Multiple ERCP procedures were required for stone extraction.
Congenital agenesis of the gallbladder was discovered during subsequent surgical exploration.

Conclusions:

Congenital agenesis of the gallbladder, though rare, can lead to symptomatic choledocholithiasis.
Patients with gallbladder agenesis have an increased risk of developing de novo choledocholithiasis.
Management of choledocholithiasis in agenesis of the gallbladder can be complex.