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Updated: Apr 6, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Targeting the Pim kinases in multiple myeloma

N A Keane1, M Reidy2, A Natoni2

  • 1Apoptosis Research Centre, National University of Ireland Galway and Department of Haematology, Galway University Hospital, Galway, Ireland.

Blood Cancer Journal
|July 18, 2015
PubMed
Summary

Multiple myeloma (MM) treatment needs novel strategies. Targeting Pim-2, a kinase upregulated in MM, offers a promising therapeutic avenue by inhibiting cancer cell survival and bone destruction.

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