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DogMATIC--A Remote Biospecimen Collection Kit for Biobanking
Kristi M Milley1,2, Judith S Nimmo3, Barbara Bacci2,4
11 School of Medical Sciences, RMIT University , Bundoora, Australia .
Biopreservation and Biobanking
|July 18, 2015
Summary
A new biobank successfully collected canine mammary tumors from rural veterinary clinics using a specialized kit. This resource supports comparative oncology research and breast cancer studies.
Area of Science:
- Comparative oncology
- Veterinary medicine
- Biobanking
Background:
- Canine tumors serve as valuable models for human cancer research.
- Canine mammary tumors (CMTs) are common and managed primarily in local veterinary settings.
- Establishing a well-characterized biobank is crucial for advancing CMT research.
Purpose of the Study:
- To create a sustainable biobank of CMTs for breast cancer research.
- To provide a characterized sample cohort for specimen sharing and data mining.
- To establish a long-term, sustainable comparative oncology research resource in Australia.
Main Methods:
- A biobank framework utilizing numerous participating veterinary clinics as collection centers was adopted.
- A specialized collection kit (DogMATIC) was designed for remote collection of fresh and fixed tissues.
- The methodology was validated by analyzing kit design, collection rates, and sample quality.
Main Results:
- The Australian Veterinary Cancer Biobank was established, comprising 47 veterinary clinics and 3 pathology laboratories.
- Over 30 CMT cases were collected within the first 12 months using the DogMATIC kit.
- High-quality RNA (pure, intact) was isolated from over 80% of samples, with an average yield of 14.49 μg.
Conclusions:
- A large-scale, decentralized biobank for canine mammary tumors was successfully established and coordinated.
- The DogMATIC kit facilitates efficient sample collection from remote veterinary locations.
- This initiative provides a vital, sustainable resource for comparative oncology and breast cancer research.
