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Updated: Apr 6, 2026

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
One-pot sonochemical synthesis of ferrocenyl derivatives via a three-component reaction in aqueous media
Luca Cappelletti1, Luca Vaghi1, Laura Rinaldi2
1Dipartimento di Scienza e Alta Tecnologia, University of Insubria, Via Valleggio 11, 22100 Como, Italy.
Abstract:
An ultrasound-assisted three-component, one-pot domino reaction with ferrocenecarboxaldehyde is herein reported. The sequence of reactions entails the allylindation and dehydrative alkylation of stabilized C-nucleophiles (e.g. electron-rich-(hetero)aromatics and stabilized enols) and N-nucleophiles (e.g. azoles). Sonochemical reactions have been performed in three different high-intensity reactors: a bath (20.3 kHz, 60 W), as well as two cup horns working at 19.9 kHz (75 W) and 300.5 kHz (70 W) giving a library of 18 new ferrocenyl derivatives.
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