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Updated: Apr 6, 2026

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
Published on: July 14, 2016
Aging-related magnification of genetic effects on cognitive and brain integrity
Goran Papenberg1, Ulman Lindenberger2, Lars Bäckman1
1Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Abstract:
Heritability studies document substantial genetic influences on cognitive performance and decline in old age. Increasing evidence shows that effects of genetic variations on cognition, brain structure, and brain function become stronger as people age. Disproportionate impairments are typically observed for older individuals carrying disadvantageous genotypes of different candidate genes. These data support the resource-modulation hypothesis, which states that genetic effects are magnified in persons with constrained neural resources, such as older adults. However, given that findings are not unequivocal, we discuss the need to address several factors that may resolve inconsistencies in the extant literature (gene-gene and gene-environment interactions, study populations, gene-environment correlations, and epigenetic mechanisms).
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