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Trabecular bone score in type 1 diabetes--a cross-sectional study.

T Neumann1, S Lodes2, B Kästner2

  • 1Department of Internal Medicine III, Erlanger Allee 101, Jena University Hospital, 07747, Jena, Germany. thomas.neumann@med.uni-jena.de.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
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Summary
This summary is machine-generated.

Trabecular bone score (TBS) can help identify fractures in type 1 diabetes (T1D) patients. Lower TBS values in T1D patients with fractures suggest altered bone strength, indicating TBS

Keywords:
BoneFractureTrabecular bone scoreType 1 diabetes

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Area of Science:

  • Endocrinology
  • Orthopedics
  • Radiology

Background:

  • Type 1 diabetes (T1D) is associated with an increased risk of osteoporotic fractures.
  • Trabecular Bone Score (TBS) is a novel method to assess bone microarchitecture indirectly.
  • The role of TBS in T1D patients with prevalent fractures requires further investigation.

Purpose of the Study:

  • To investigate Trabecular Bone Score (TBS) in type 1 diabetes (T1D) patients compared to healthy controls.
  • To assess the association between TBS and prevalent fractures in T1D patients.
  • To evaluate the predictive value of TBS for fractures in T1D.

Main Methods:

  • A cohort of 119 T1D patients and 68 matched healthy controls were analyzed.
  • TBS was calculated from lumbar spine DXA scans.
  • Associations between TBS, HbA1c, and prevalent fractures were examined.

Main Results:

  • TBS did not significantly differ between T1D patients and controls (p=0.075).
  • T1D patients with prevalent fractures exhibited significantly lower TBS compared to those without fractures (p=0.04).
  • Lower TBS (OR=0.024) and higher HbA1c were independently associated with prevalent fractures in T1D.

Conclusions:

  • Lower TBS values in T1D patients with prevalent fractures suggest compromised bone strength.
  • TBS may offer additive value to BMD in identifying fracture risk in T1D.
  • Larger prospective studies are needed to establish reliable TBS cutoffs for fracture risk prediction in T1D.