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Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012
Raymond James Mullins1, Keith B G Dear2, Mimi L K Tang3
1John James Medical Centre, Deakin, Canberra, Australia; Medical School, Australian National University Canberra, Canberra, Australia; Health Sciences, University of Canberra, Bruce, Canberra, Australia.
Insights
Childhood food allergy and anaphylaxis admissions continue to rise, with significant increases observed in all age groups. The data suggests an accelerating trend, particularly in school-aged children, indicating a growing public health concern.
Area of Science:
- Pediatric Allergy and Immunology
- Public Health Surveillance
- Epidemiology of Allergic Diseases
Background:
- Previous studies indicated rising childhood food allergy and anaphylaxis rates in the UK, US, and Australia post-1990.
- The prevalence of food allergy and severe allergic reactions in children has been a growing concern globally.
Purpose of the Study:
- To investigate the continued trend of childhood food allergy and anaphylaxis prevalence since 2004-2005.
- To update the understanding of anaphylaxis admission rates in various age demographics.
Main Methods:
- Analysis of hospital admission data for anaphylaxis between 2005-2006 and 2011-2012.
- Comparison of recent admission rates with historical data from 1998-1999 to 2004-2005.
Main Results:
- Food-related anaphylaxis admission rates increased by 1.5-fold overall between 2005-2006 and 2011-2012.
- The 5-14 year age group showed the largest proportionate increase (2.1-fold), while the 0-4 year group maintained the highest rates.
- A statistically significant increase in the year-on-year rate of anaphylaxis admissions was observed over time.
Conclusions:
- Food-related anaphylaxis has continued to increase across all age demographics since 2004-2005.
- While young children (0-4 years) bear the highest burden, there's evidence of accelerated incidence in school-aged children (5-14 years).
- Findings suggest a potential rise in anaphylaxis cases among adolescents and adults, a group at higher risk for fatal outcomes.
Background:
Studies from the United Kingdom, the United States, and Australia have reported increased childhood food allergy and anaphylaxis prevalence in the 15 years after 1990.
Objective:
We sought to examine whether childhood food allergy/anaphylaxis prevalence has increased further since 2004-2005.
Methods:
We examined hospital anaphylaxis admission rates between 2005-2006 and 2011-2012 and compared findings with those from 1998-1999 to 2004-2005.
Results:
Overall population food-related anaphylaxis admission rates (per 10(5) population per year) increased from 5.6 in 2005-2006 to 8.2 in 2011-2012 (a 1.5-fold increase over 7 years). The highest rates occurred in children aged 0 to 4 years (21.7 in 2005-2006 and 30.3 in 2011-2012, a 1.4-fold increase), but the greatest proportionate increase occurred in those aged 5 to 14 years (5.8-12.1/10(5) population/y, respectively, a 2.1-fold increase) compared with those aged 15 to 29 years and 30 years or older (a 1.5- and 1.3-fold increase, respectively). Not only did absolute food-related anaphylaxis admissions increase, but the modeled year-on-year rate of increase in overall food-related anaphylaxis admissions also increased over time from an additional 0.35 per 10(5) population/y in 1998-1999 (all ages) to 0.49 in 2004-2005 and 0.63 in 2011-2012 (P < .001).
Conclusions:
Food-related anaphylaxis has increased further in all age groups since 2004-2005. Although the major burden falls on those aged 0 to 4 years, there is preliminary evidence for a recent acceleration in incidence rates in those aged 5 to 14 years. This contrasts with the previous decade in which the greatest proportionate increase was in those aged 0 to 4 years. These findings suggest a possible increasing burden of disease among adolescents and adults who carry the highest risk for fatal anaphylaxis.
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