Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population
Priyanka Mishra1, Kashi Nath Prasad1, Kamini Singh1
1Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Objective:
Brain abscess develops in response to a parenchymal infection with pyogenic bacteria. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are the most crucial pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. The present study evaluated the association of specific alleles/genotypes of TNF-α and IL-1β with brain abscess.
Material And Methods:
A total of 90 brain abscess patients and 100 healthy controls were included in the study. Predisposing factors were identified in 56 (62.2%) patients with brain abscess. TNF-α (-308 G>A) and IL-1β (-511 C
Results:
TNF-α genotypes AA and GA (p<0.001 for AA and p=0.001 for GA), and IL-1β genotypes C/C and C/T (p<0.001 for C/C and p=0.049 for C/T) were significantly associated with brain abscess. Homozygous AA genotype of TNF-α had significant association with brain abscess patients having identified predisposing factors (p=0.026). Patients with heterozygous or homozygous A allele in TNF-α (-308 G>A) and C allele in IL-1β (-511 C
Conclusion:
TNF-α (-308 G>A) and IL-1β (-511 C
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