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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
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Photosensitivity with Angiotensin II Receptor Blockers: A Retrospective Study Using Data from VigiBase(®).

Ermelinda Viola1, Anna Coggiola Pittoni2, Agnes Drahos3

  • 1Pharmacology Unit, Department of Public Health and Community Medicine, University of Verona, P.le L.A. Scuro, 10, 37134, Verona, Italy. ermelinda.viola@univr.it.

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Summary
This summary is machine-generated.

Photosensitivity reactions are linked to Angiotensin II receptor blockers (ARBs). Irbesartan and losartan showed a possible correlation, suggesting photosensitivity may be a class effect for ARBs.

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Area of Science:

  • Pharmacovigilance
  • Dermatology
  • Cardiology

Background:

  • Angiotensin II receptor blockers (ARBs) are common treatments for hypertension and heart failure.
  • Photosensitivity reactions are adverse skin events triggered by drug exposure and UV or visible light.
  • Currently, only losartan is officially labeled for photosensitivity within the ARB class.

Purpose of the Study:

  • To evaluate photosensitivity reports associated with ARBs using the World Health Organization's VigiBase database.
  • To analyze the characteristics and disproportionality of photosensitivity reactions across different ARBs.

Main Methods:

  • Retrieved all photosensitivity reports for ARBs from VigiBase.
  • Analyzed report variables, including disproportionality using Information Component (IC) and IC025.
  • Assessed report quality using VigiGrade completeness score, focusing on well-documented cases (C > 0.8).

Main Results:

  • 203 photosensitivity reports involving ARBs were recorded globally by December 2014.
  • Losartan (25.1%), irbesartan (23.1%), and valsartan (21.7%) were most frequently reported.
  • Positive disproportionality for photosensitivity was observed with irbesartan and losartan. In well-documented cases, losartan, olmesartan, and irbesartan were notably associated.

Conclusions:

  • Photosensitivity reactions are reported across most ARBs, with irbesartan and losartan showing significant disproportionality.
  • Given structural similarities, photosensitivity may be a class effect of ARBs.
  • Healthcare providers and patients should be vigilant regarding potential photosensitivity reactions during ARB therapy.