Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffuse axonal injury after severe head trauma. A clinico-pathological study.

J Sahuquillo1, J Vilalta, J Lamarca

  • 1Department of Neurosurgery, Vall d'Hebron Hospital, Autonomous University of Barcelona, School of Medicine, Spain.

Acta Neurochirurgica
|January 1, 1989
PubMed
Summary

Diffuse Axonal Injury (DAI), a common finding in severe head trauma, occurs with or without visible mass lesions on CT scans. Postmortem examinations confirmed DAI in patients with immediate coma following trauma.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary loss of endothelial regeneration after ripasudil associated with delayed allergic contact dermatitis.

Journal francais d'ophtalmologie·2026
Same author

A review of <i>Hyphodiscaceae</i>.

Studies in mycology·2023
Same author

Carriage of multidrug-resistant Gram-negative bacilli: duration and risk factors.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2023
Same author

[2022 Practice guidelines for the management of arterial hypertension of the Spanish Society of Hypertension].

Hipertension y riesgo vascular·2022
Same author

2021 Spanish Society of Hypertension position statement about telemedicine.

Hipertension y riesgo vascular·2021
Same author

Fungal Planet description sheets: 1042-1111.

Persoonia·2020

Area of Science:

  • Neuropathology
  • Trauma Medicine
  • Forensic Pathology

Background:

  • Diffuse Axonal Injury (DAI) is a critical consequence of severe head trauma.
  • It is often associated with immediate coma and negative CT scans for mass lesions.
  • DAI results from high-magnitude shear and tensile strains, typically from rotational acceleration.

Purpose of the Study:

  • To present findings on DAI in a cohort of severe head injury patients.
  • To analyze the occurrence of DAI with and without CT-evident mass lesions.
  • To describe the pathological characteristics of DAI.

Main Methods:

  • Postmortem examination of 24 severe head injury patients.
  • Histological analysis focusing on axonal retraction balls.

Related Experiment Videos

  • Categorization into subgroups based on CT scan findings (mass lesions vs. no mass lesions).

    • Main Results:

    • Unequivocal signs of DAI were found in all 24 patients.
    • Widespread axonal retraction balls were the predominant histological finding, especially in the centrum semiovale and internal capsule.
    • DAI was present in 15 patients with no CT mass lesions and in 9 patients with associated mass lesions (hematomas).

    Conclusions:

    • Diffuse brain damage, including DAI, is common in severe head injuries with immediate coma, even without CT mass lesions.
    • DAI can co-exist with various focal lesions such as subdural or intracerebral hematomas.
    • Rotational acceleration mechanisms are strongly implicated in DAI development.