Cholesterol efflux capacity in humans with psoriasis is inversely related to non-calcified burden of coronary atherosclerosis
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Summary
This summary is machine-generated.Cholesterol efflux capacity (CEC) is linked to coronary plaque burden in psoriasis patients. Low CEC may indicate subclinical coronary atherosclerosis, highlighting its potential as a biomarker.
Area Of Science
- Cardiovascular Medicine
- Dermatology
- Biochemistry
Background
- Psoriasis is associated with increased cardiovascular (CV) risk and impaired cholesterol efflux capacity (CEC).
- The relationship between poor CEC and coronary plaque burden in psoriasis patients remains unclear.
- This study investigates the association between CEC and subclinical coronary atherosclerosis in a psoriasis cohort.
Purpose Of The Study
- To assess the cross-sectional relationship between coronary plaque burden, measured by quantitative coronary computed tomography angiography (CCTA), and CEC in psoriasis patients.
- To determine if low CEC is associated with prevalent coronary atherosclerosis in this population.
Main Methods
- 101 psoriasis patients underwent quantitative CCTA to assess total and non-calcified plaque burden (NCB).
- CEC was measured using an ex vivo cell-based assay.
- Statistical analyses were performed to evaluate the association between CEC and plaque indices, adjusting for CV risk factors.
Main Results
- CEC was inversely correlated with NCB (β -0.33; P < 0.001), persisting after adjustments.
- This inverse association remained significant after adjusting for HDL-C and apoA1 levels.
- A significant gender interaction was observed, with women with low CEC exhibiting higher NCB than men with low CEC.
Conclusions
- CEC is inversely associated with prevalent coronary plaque burden in psoriasis patients.
- Low CEC may serve as a valuable biomarker for subclinical coronary atherosclerosis in individuals with psoriasis.