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Inverse association between diabetes and aortic dilatation in patients with advanced coronary artery disease

Akihito Tanaka1, Hideki Ishii1, Hideki Oshima2

  • 1The Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Atherosclerosis
|July 20, 2015
PubMed

Insights

Diabetes is associated with smaller aortic diameters in patients with coronary artery disease. This study found that individuals with diabetes mellitus had significantly reduced infrarenal and ascending aorta sizes compared to those without diabetes.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Vascular Surgery

Background:

  • Recent studies suggest a negative association between diabetes and abdominal aortic aneurysm.
  • Understanding this relationship is crucial for managing cardiovascular risk in diabetic patients.

Purpose of the Study:

  • To investigate the relationship between diabetes and aortic diameter, including non-aneurysmal measurements.
  • To assess aortic dimensions in patients with advanced coronary artery disease and diabetes mellitus.

Main Methods:

  • A cohort of 351 patients undergoing coronary artery bypass graft surgery was analyzed.
  • Patients were categorized into diabetes mellitus (DM+) and non-diabetes (DM-) groups.
  • Infrarenal and ascending aortic diameters were measured using preoperative computed tomography and adjusted for body surface area.

Main Results:

  • The DM+ group exhibited significantly smaller infrarenal and ascending aortic diameters compared to the DM- group.
  • Lower prevalence of infrarenal aortic diameter ≥30 mm and ascending aortic diameter ≥40 mm was observed in the DM+ group.
  • Diabetes was identified as an independent predictor of smaller aortic diameters in both infrarenal and ascending aorta segments.

Conclusions:

  • Diabetes mellitus is inversely associated with aortic dilatation in both the infrarenal and ascending aorta.
  • These findings highlight a potential protective effect of diabetes against aortic enlargement in this patient population.
  • Further research may explore the mechanisms underlying this inverse relationship.
Abstract

Keywords:
Advanced coronary artery diseaseAortic dilatationDiabetes

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