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Updated: Apr 6, 2026

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[Disproportion between placenta weight and birth weight: Physiologic or pathologic].

P Lorain1, J Boujenah1, A Bricou1

  • 1Service de gynécologie-obstétrique, CHU Jean-Verdier, université Paris XIII - Bobigny, avenue du 14-Juillet, 93143 Bondy cedex, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|July 20, 2015
PubMed
Summary
This summary is machine-generated.

A high placental weight to birth weight ratio (PW/BW) is linked to increased pre-eclampsia risk in term pregnancies. This finding suggests complex underlying conditions contribute to placentomegaly and adverse outcomes.

Keywords:
Birth weightPerinatalPlacenta weightPlacentomegalyPlacentomégaliePoids de naissancePoids placentairePre-eclampsiaPré-éclampsiePérinatal

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Reproductive Biology

Background:

  • The placental weight to birth weight ratio (PW/BW) is a key indicator of placental health.
  • Abnormal PW/BW ratios may signify underlying placental dysfunction and impact pregnancy outcomes.

Purpose of the Study:

  • To investigate the association between a high placental weight to birth weight ratio (PW/BW) and maternal/neonatal outcomes.
  • To identify potential risk factors associated with elevated PW/BW ratios.

Main Methods:

  • A retrospective, population-based study comparing pregnancies with high PW/BW (>0.25) to controls (PW/BW 0.15-0.25).
  • Maternal and neonatal outcomes were analyzed between the two groups.

Main Results:

  • The high PW/BW group showed significantly higher rates of pre-eclampsia (15.5% vs 1.7%) and small for gestational age infants (8% vs 0%).
  • After adjusting for confounding factors, no significant differences in maternal risk factors or neonatal outcomes were observed.

Conclusions:

  • Elevated placental weight to birth weight ratio, indicative of placentomegaly, is associated with an increased risk of pre-eclampsia in term pregnancies.
  • The pathogenesis of high PW/BW involves a mix of conditions contributing to placental abnormalities.