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Updated: Apr 6, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
[Disproportion between placenta weight and birth weight: Physiologic or pathologic]
P Lorain1, J Boujenah1, A Bricou1
1Service de gynécologie-obstétrique, CHU Jean-Verdier, université Paris XIII - Bobigny, avenue du 14-Juillet, 93143 Bondy cedex, France.
Objectives:
To study risk factors, maternal and neonatal outcome with a high placental weight to birth weight ratio (PW/BW).
Materials And Methods:
Two groups of full term singleton pregnancies were created in this single centre retrospective population-based study (a high PW/BW above 0.25 and group control with normal PW/BW between 0.15 and 0.25). Maternal and neonatal outcomes were compared.
Results:
Compared with the group with normal PW/BW ratios, the high PW/BW ratio group was associated with increased rates of pre-eclampsia (15.5% versus 1.7%, P<0.05) and small for gestational age (8% versus 0%, P<0.05). Neither maternal risk factors nor neonatal outcome difference were shown after adjusting confounding factors.
Conclusion:
High PW/BW with placentomegaly is associated with increased risk of pre-eclampsia at term underlying a mixture of condition in its pathogenesis.
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