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Alkyl esters of L-ascorbic acid: Stability, surface behaviour and interaction with phospholipid monolayers

Milagro Mottola1, Raquel V Vico2, Martín E Villanueva2

  • 1Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC-CONICET), Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina; Instituto de Investigaciones en Fisicoquímica de Córdoba (INFIQC-CONICET), Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina.

Journal of Colloid and Interface Science
|July 20, 2015
PubMed
Summary

L-ascorbic acid alkyl esters (ASCn) are stable, amphiphilic compounds with pharmaceutical potential. Longer chain ASCn molecules exhibit significant surface activity and interact with lipid membranes, influencing their pharmacological effects.

Keywords:
Amphiphilic Vitamin C derivativesAscorbic acid tautomerizationChiral crystalline domainsGibbs adsorption filmsLangmuir monolayersPhospholipids mixed domains

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