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Related Experiment Video

Updated: Apr 6, 2026

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Equine recurrent uveitis: Human and equine perspectives.

Fernando Malalana1, Amira Stylianides2, Catherine McGowan3

  • 1The Philip Leverhulme Equine Hospital, The University of Liverpool, Leahurst Campus, Neston, Wirral, CH64 7TE, UK.

Veterinary Journal (London, England : 1997)
|July 20, 2015
PubMed
Summary

Equine recurrent uveitis (ERU) is an autoimmune eye disease more common in horses than humans. Research explores ERU

Keywords:
AutoimmuneEquine recurrent uveitisIntraocular inflammationLeptospira spp

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Area of Science:

  • Veterinary Ophthalmology
  • Immunology
  • Genetics

Background:

  • Equine recurrent uveitis (ERU) is a spontaneous autoimmune disease causing repeated intraocular inflammation in horses.
  • ERU is significantly more prevalent in horses than human recurrent uveitis, with breed and geographic predispositions noted.
  • Both species exhibit altered immune responses and autoimmune mechanisms, but inciting factors remain unclear.

Purpose of the Study:

  • To review the immunology and genetics of equine recurrent uveitis (ERU).
  • To compare ERU in horses with autoimmune anterior uveitis in humans.
  • To explore reasons for the higher prevalence of ERU in horses.

Main Methods:

  • Literature review focusing on equine ophthalmology, immunology, and genetics.
  • Comparative analysis of ERU in horses and human uveitis.
  • Discussion of potential microbial and genetic risk factors.

Main Results:

  • ERU shares autoimmune pathophysiology with human uveitis but has a higher prevalence in horses.
  • Potential triggers include microbial agents like Leptospira spp.
  • Genetic predisposition is a significant factor in equine susceptibility.

Conclusions:

  • Understanding the immunology and genetics of ERU is crucial for explaining its prevalence in horses.
  • Microbial factors and host genetics likely interact to increase ERU susceptibility.
  • Further research is needed to fully elucidate ERU's etiology and develop targeted therapies.