Related Experiment Video
Updated: Apr 6, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
Published on: April 3, 2015
The regulation of immune cell trafficking by the extracellular matrix
Rupert Hallmann1, Xueli Zhang1, Jacopo Di Russo1
1Institute of Physiological Chemistry and Pathobiochemistry and Cells-in-Motion Cluster of Excellence, University of Muenster, Germany.
Abstract:
The extracellular matrix (ECM) comes in different structural forms and biochemical compositions, which determine both its biophysical properties and its ability to convey specific signals to immune cells encountering or navigating through it. Traditionally, the role of the individual ECM molecules on cell migration has been investigated independent of considerations such as the tension/mechanical strength constituted by the ECM. However, more recently, this aspect has attracted considerable attention and data suggest that rigidity and molecular signals derived from the ECM define the mode of cell migration. We here review the different types of ECM encountered by migrating immune cells in vivo, as well as current information on how both molecular components of the ECM and their supramolecular structure can impact on modes of immune cell migration.
More Related Videos
09:11Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
Published on: February 19, 2015
06:42Author Spotlight: Understanding Disease Mechanisms Through Real-Time Analysis of T-Cell Migration
Published on: May 24, 2024
Related Concept Videos
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
Overview of Cell-Matrix Interactions
Extracellular Matrix
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Intracellular Signaling Affects Focal Adhesions
Some...