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Systemic amyloidosis with bilateral conjunctival involvement: a case report.

Leandro J Correa1, J Pablo Maccio2, Evangelina Esposito3

  • 1Department of Ophthalmology, University Clinic Reina Fabiola, Universidad Catolica de Cordoba, Oncativo 1248, Cordoba, 5000, Argentina. leandrocorrea50@hotmail.com.

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This case study highlights a rare instance of systemic amyloidosis presenting with bilateral conjunctival involvement. Early diagnosis and differentiation from other conditions are crucial for effective management.

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Area of Science:

  • Ophthalmology
  • Pathology
  • Internal Medicine

Background:

  • Conjunctival amyloidosis is a rare condition, typically unilateral and isolated.
  • Systemic compromise is uncommon in most conjunctival amyloidosis cases.

Observation:

  • A 66-year-old female presented with bilateral conjunctival hemorrhage and chemosis.
  • Biopsies confirmed amyloid deposits in the conjunctiva, esophagus, and rectus, with increased plasma cells and kappa light chain overexpression in bone marrow.

Findings:

  • The patient was diagnosed with systemic amyloidosis with bilateral conjunctival involvement.
  • Treatment with corticosteroids and lubrication improved symptoms, with ocular lesions remaining stable over 3 years.

Implications:

  • Conjunctival amyloidosis can be an indicator of systemic disease.
  • It is essential to rule out systemic involvement in suspected conjunctival amyloidosis cases.
  • Differentiating from chronic conjunctivitis and malignancies is critical.