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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
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Published on: June 2, 2019

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Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies

Anna Villar-Piqué1, Tomás Lopes da Fonseca1,2, Tiago Fleming Outeiro3,4,5

  • 1Department of NeuroDegeneration and Restorative Research, Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Göttingen, Göttingen, Germany.

Journal of Neurochemistry
|July 21, 2015
PubMed
Summary

Parkinson's disease and related synucleinopathies involve alpha-synuclein protein misfolding. Understanding its structure, function, and toxicity is key to developing new therapies for these neurodegenerative disorders.

Keywords:
alpha-synucleinamyloid fibrilsoligomerssynapsessynucleinopathies

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