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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
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Metabolomics in the pharmaceutical industry.
Michael D Reily1, Adrienne A Tymiak1
1Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Co., Princeton, NJ, USA.
Drug Discovery Today. Technologies
|July 21, 2015
Summary
Metabolomics, a field with pharmaceutical roots, now reveals drug responses and biological processes. This technology is key for advancing drug discovery and development.
Area of Science:
- Pharmaceutical Science
- Biochemistry
- Systems Biology
Background:
- Metabolomics has a 30-year history in the pharmaceutical industry.
- Early applications focused on toxicology and disease pathology.
- Recent advancements have positioned metabolomics as a tool for understanding biological processes and drug responses.
Purpose of the Study:
- To discuss the impact of metabolomic technologies in pharmaceutical research.
- To highlight key areas for future applications in drug discovery and development.
Main Methods:
- Review of metabolomic technologies.
- Analysis of current and emerging applications in pharmaceutical R&D.
Main Results:
- Metabolomics provides insights into molecular mechanisms of biological processes.
- It aids in understanding pharmacological responses to drugs.
- Key areas for impact include drug discovery and development.
Conclusions:
- Metabolomic technologies are crucial for advancing pharmaceutical R&D.
- The field is poised to significantly impact drug discovery and development processes.
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