A case of pancreatic solid-pseudopapillary neoplasm with marked ossification

Area of Science:

• Gastroenterology
• Oncology
• Radiology

Background:

• Pancreatic solid-pseudopapillary neoplasms (SPNs) are rare tumors, typically affecting young women.
• Ossification within an SPN is an exceptionally uncommon finding, posing diagnostic challenges.

Purpose of the Study:

• To report a unique case of pancreatic SPN with ossification.
• To discuss the diagnostic modalities and histopathological features of this rare entity.

Main Methods:

• A case study of a 25-year-old female with an incidentally discovered pancreatic lesion.
• Diagnostic imaging included computed tomography (CT), magnetic resonance imaging (MRI), and endoscopic ultrasound.
• Surgical resection and histopathological examination with immunohistochemistry were performed.

Main Results:

• Imaging revealed a pancreatic body mass with significant ossification (calcification).
• Histopathology confirmed a solid-pseudopapillary neoplasm with ossification and positive α1-antitrypsin staining.
• The tumor measured approximately 20-25 mm and showed infiltration of surrounding tissue.

Conclusions:

• Pancreatic SPN with ossification is a rare but distinct clinicopathological entity.
• Multimodality imaging is crucial for suspecting SPN, especially with atypical features like ossification.
• Surgical resection remains the primary treatment for pancreatic SPN.