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From the Reticuloendothelial to Mononuclear Phagocyte System - The Unaccounted Years

Simon Yona1, Siamon Gordon2

  • 1University College London , London , UK.

Frontiers in Immunology
|July 21, 2015
PubMed

Insights

This review traces the historical development of macrophage research from Metchnikoff's discovery of phagocytosis to the establishment of the mononuclear phagocyte system. It highlights key milestones in understanding these vital immune cells.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Ilya Metchnikoff first described phagocytosis over 125 years ago.
  • Macrophage research evolved through the reticuloendothelial system era.
  • Substantial literature exists on macrophages across immunology, hematology, biochemistry, and pathology.

Purpose of the Study:

  • To review the historical origins and development of macrophage research.
  • To examine the evolution of understanding macrophage diversity and function.
  • To commemorate the 50th anniversary of the mononuclear phagocyte system nomenclature.

Main Methods:

  • Historical literature review.
  • Analysis of early histological studies on cell morphology.
  • Examination of in situ labeling techniques.

Main Results:

  • Early studies established the foundations for appreciating macrophage diversity.
  • Histological and labeling methods revealed cellular capacity in steady state and pathology.
  • The review covers research from Metchnikoff's era to the present.

Conclusions:

  • Macrophage research has a rich history spanning multiple scientific disciplines.
  • Understanding macrophage morphology and function is crucial in health and disease.
  • The establishment of the mononuclear phagocyte system nomenclature marked a significant milestone.
Keywords:
Metchnikoffdendritic cellsinflammationmacrophagemonocytephagocytosis

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