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Related Concept Videos

Migration00:53

Migration

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Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.
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Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Chemotaxis and Direction of Cell Migration01:21

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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Cytoskeletal Coordination in Cell Migration01:32

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A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
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What is a Mode?01:07

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The mode is one of the commonly used measures of a central tendency. It is defined as the most frequent value in a data set.
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A data set with two modes is called bimodal. For example,...
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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro
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Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

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Physical view on migration modes.

Claudia Tanja Mierke1

  • 1a Faculty of Physics and Earth Science; Institute of Experimental Physics I; Biological Physics Division; University of Leipzig ; Leipzig , Germany.

Cell Adhesion & Migration
|July 21, 2015
PubMed
Summary
This summary is machine-generated.

Cellular migration modes, crucial for development and disease, are explored through a physical lens. Understanding mechanical factors driving cell movement and transitions between modes like amoeboid and mesenchymal is key.

Keywords:
acto-myosin cytoskeletonblebbingcell invasioncellular stiffnesscontractile forcescytoskeletal remodelingfocal adhesionsintegrinsintermediate filamentsmatrix-metalloproteasestransendothelial migration

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Area of Science:

  • Cell Biology
  • Biophysics
  • Cancer Research

Background:

  • Cellular motility is vital for embryonic development, wound healing, tissue regeneration, immune response, and cancer metastasis.
  • Existing migration mode classifications (epithelial, mesenchymal, amoeboid) rely on morphology and gene expression, with limited understanding of underlying physical principles.
  • Cancer cell migration and metastasis are significantly influenced by the specific migration mode employed.

Purpose of the Study:

  • To review different cellular migration strategies from a physical perspective.
  • To identify the mechanical prerequisites for cells to adopt specific migration modes within a 3D microenvironment.
  • To explore how cells switch between migration modes and the impact of physical properties on these transitions.

Main Methods:

  • Review of existing literature on cellular migration modes.
  • Analysis of phenomenological and molecular biological criteria for migration.
  • Discussion of physical and mechanical factors influencing cell migration and mode switching.

Main Results:

  • The physical basis of cellular migration modes is not well understood.
  • Mechanical prerequisites are necessary for cells to perform specific migration modes in 3D environments.
  • Cellular and microenvironmental physical properties influence transitions between migration modes, including blebbing and protrusive motility.

Conclusions:

  • A deeper understanding of the physical aspects of cell migration is needed.
  • Mechanical factors are critical for determining and switching between cellular migration modes.
  • Investigating the physical properties of cells and their environment is essential for understanding cancer metastasis and other biological processes.