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Updated: Apr 6, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
The histopathological study of radicular dentinal changes in patients with chronic marginal periodontopathies
Melania Olimpia Cojocaru1, Elvira Florina Pătroi, Dorina Corlan Puşcu
1Department of Histology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; laurentiu_mogoanta@yahoo.com.
Abstract:
Periodontal disease is one of the most frequent conditions in individuals, having major health and social implications. Progressing as a chronic inflammation at the level of tooth support tissues, untreated chronic periodontitis may lead to a premature loss of the dental organ. Even though the main lesions caused by the periodontal disease affect the alveolo-dental ligaments, we tried to highlight the presence of certain lesions of radicular dentine in patients with chronic marginal periodontopathy. In our study, in the patients with chronic marginal periodontopathy, at periodontium level, there was highlighted the presence of a chronic inflammatory process with numerous lymphocytes and macrophages, microhemorrhages, and also areas with tissular necrosis. At radicular dentine level, in the cases of old, untreated periodontal disease, there were observed areas of more or less extended demineralization, erosion and necrosis. Our study showed that chronic periodontal disease may affect the tooth, as well, not only its support tissues.

