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Localized laryngeal amyloidosis - a case report
Mihály Szőcs1, Gheorghe Mühlfay, Simona Liliana Mocan
1Department of Otolaryngology, University of Medicine and Pharmacy of Tirgu Mures, Romania; ghe.muhlfay@gmail.com.
Summary
This case study highlights a rare instance of laryngeal amyloidosis, a condition involving abnormal protein deposits. Diagnosis and surgical treatment were successfully managed in a 49-year-old woman presenting with voice and breathing difficulties.
Area of Science:
- Pathology
- Otolaryngology
- Oncology
Background:
- Amyloidosis is a group of diseases characterized by extracellular protein fibril deposition, affecting cell and organ function.
- It can manifest as localized or systemic, hereditary or acquired conditions, often linked to chronic inflammation or hematological disorders.
Observation:
- A 49-year-old woman presented with dysphagia, dysphonia, and dyspnea, initially suspected as a laryngeal tumor.
- Microlaryngoscopy and biopsy revealed amyloidosis as the underlying pathology, not a malignant tumor.
Findings:
- Histopathological examination confirmed amyloidosis in the laryngeal biopsy specimen.
- Surgical excision of the laryngeal amyloid deposit was performed.
Implications:
- This case underscores the importance of considering rare pathologies like laryngeal amyloidosis in the differential diagnosis of obstructive airway symptoms.
- Effective management involves accurate histopathological diagnosis and appropriate surgical intervention for favorable patient outcomes.
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