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Updated: Apr 6, 2026

Flow Cytometric Characterization of Murine B Cell Development
Published on: January 22, 2021
B cells in the aging immune system: time to consider B-1 cells
Nichol E Holodick1, Thomas L Rothstein1,2
1Center for Oncology and Cell Biology, The Feinstein Institute for Medical Research, Manhasset, New York.
Abstract:
The investigation of immune senescence has uncovered many changes in B cell development, maintenance, and function with increasing age. However, most of these studies have focused on conventional B cell subsets in the spleen. The B-1 cell subset is an essential arm of the innate immune system, which in general has been understudied in terms of immune senescence. Here, we review what is currently known about B cells during aging and go on to describe why B-1 cell biology is an important component of the aging immune system in the context of diseases that most affect the aged population.
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