Effect of statins on preventing infectious complications after surgery: Systematic review and meta-analysis
Bao-Xin Ma1, Hua Li2, Jing-Sen Li2
1Department of Cardiology, Affiliated Hospital of Binzhou Medical University, Binzhou, China sfdbh2006@sohu.com.
Objective:
*These authors contributed equally to this work.A meta-analysis to investigate the association between preoperative statin use and the risk of postoperative infectious complications in patients undergoing surgery.
Methods:
PubMed(®) and Embase(®) databases were searched for relevant studies. Data were extracted using a standardized data collection form. The primary effect measure was the odds ratio (OR) of postoperative infectious complications. Summary OR were calculated.
Results:
The analysis included 10 cohort studies with a total of 147 263 participants. Statin use was associated with a lower incidence of postoperative infectious complications in all studies (summary OR 0.917, 95% confidence intervals [CI] 0.862, 0.975, fixed-effects model; summary OR 0.731, 95% CI 0.584, 0.870, random-effects model); cardiac surgery (summary OR 0.673; 95% CI 0.535, 0.847); treatment in the USA (summary OR 0.678; 95% CI 0.597, 0.770); retrospective cohort studies (summary OR 0.664; 95% CI 0.521, 0.846).
Conclusion:
Preoperative statin use is associated with a reduced risk of postoperative infectious complications.
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