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Bidirectional triggering association between migraine and restless legs syndrome: A diary study
Ping-Kun Chen1, Jong-Ling Fuh2, Shuu-Jiun Wang3
1Department of Neurology, Lin-Shin Hospital, Taiwan Department of Neurology, China Medical University Hospital, Taiwan School of Medicine, China Medical University, Taiwan.
Cephalalgia : an International Journal of Headache
|July 22, 2015
Summary
Migraine attacks can trigger subsequent restless legs syndrome (RLS) attacks, with a stronger association than RLS triggering migraine. This study reveals a bidirectional link between these conditions.
Area of Science:
- Neurology
- Sleep Medicine
- Headache Medicine
Background:
- Migraine and restless legs syndrome (RLS) frequently occur together.
- The temporal relationship between migraine and RLS attacks is not well understood.
Purpose of the Study:
- To investigate the temporal association between migraine attacks and restless legs syndrome (RLS) attacks.
Main Methods:
- Recruited 30 migraine patients with RLS, excluding those with daily symptoms.
- Patients kept a two-week diary of headache and RLS attacks, rating severity.
- Used logit-normal, random-effects models to analyze temporal associations.
Main Results:
- Migraine attacks were significantly associated with subsequent RLS attacks on the same and next nights (OR=6.94 and OR=3.00).
- RLS attacks were associated with subsequent migraine attacks on Day 1 (OR=1.97).
- Migraine and RLS attack frequencies were positively correlated (Spearman's correlation=0.56).
Conclusions:
- A bidirectional triggering association exists between migraine and RLS attacks.
- The association is stronger and longer-lasting for migraine triggering RLS compared to RLS triggering migraine.
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