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Introducing Pathogen Reduction Technology in Poland: A Cost-Utility Analysis.

Maria Agapova¹, Elzbieta Lachert², Ewa Brojer²

¹Pharmaceutical Outcomes Research and Policy Program, University of Washington, Seattle, WA, USA.

Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur Transfusionsmedizin Und Immunhamatologie

|July 22, 2015

Summary

This summary is machine-generated.

Mirasol® pathogen reduction technology (PRT) is costly in Poland, but treating both plasma and platelets is more cost-effective than plasma alone. Further hemovigilance data are needed for precise health economic evaluation.

Keywords:

Blood safety Cost-effectiveness ICER Mirasol PRT Pathogen reduction technology Poland

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Area of Science:

Blood safety and transfusion medicine
Health economics and outcomes research
Medical device technology evaluation

Background:

Mirasol® pathogen reduction technology (PRT) uses UV light and riboflavin to inactivate pathogens in blood components.
PRT is CE-marked for plasma and platelet treatment in the EU.
Poland's interest in PRT for fresh frozen plasma necessitates cost-effectiveness evaluation.

Purpose of the Study:

To evaluate the incremental costs and benefits of introducing PRT into Poland's blood safety protocols.
To compare the cost-effectiveness of treating plasma alone versus both plasma and platelets with PRT.

Main Methods:

A decision-analytic model was employed to assess the economic impact of PRT.
The model evaluated costs and quality-adjusted life years (QALYs) gained.

Main Results:

PRT for plasma costs 2.595 million PLN/QALY; treating plasma and platelets costs 1.480 million PLN/QALY.
The cost per QALY in Poland is high but lower than in previous North American analyses.
Treating both plasma and platelets is more cost-effective than treating plasma only.

Conclusions:

PRT in Poland presents a high cost per QALY, though less than previously reported.
Treating both plasma and platelets offers greater cost-effectiveness than plasma treatment alone.
Significant uncertainty exists, highlighting the need for more hemovigilance data to refine economic evaluations.