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Research Findings on Overactive Bladder
1King of Prussia, Drexel University College of Medicine, Philadelphia, Pa., USA.
Current Urology
|July 22, 2015
Summary
Overactive bladder (OAB) arises from diverse conditions, affecting the urinary tract, brain, and spinal cord. Research reveals varied molecular changes, suggesting distinct OAB pathophysiologies for targeted drug development.
Area of Science:
- Urology
- Neuroscience
- Pathophysiology
Background:
- Overactive bladder (OAB) is a condition with multiple underlying physiopathologic causes.
- These causes range from aging and diabetes to neurological disorders and psychological stress.
Purpose of the Study:
- To review research findings on the physiopathology of OAB across various conditions.
- To identify common and distinct structural and functional changes associated with OAB.
Main Methods:
- Review of human and animal studies on OAB associated with conditions like aging, diabetes, neurological diseases, and stress.
- Analysis of changes in the lower urinary tract, brain, and spinal cord.
Main Results:
- Observed structural and functional changes in the lower urinary tract, brain, and spinal cord in OAB patients and animal models.
- Identified significant alterations in neurotransmitters, prostaglandins, nerve growth factor, Rho-kinase, interstitial cells of Cajal, and ion channels.
- Noted considerable variation in these alterations across different OAB-associated conditions.
Conclusions:
- The pathophysiology of OAB appears to differ based on the underlying condition.
- Understanding these variations is crucial for developing targeted OAB therapies.
- This review provides a foundation for future research into specific OAB drug development.
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