Macrolide-Resistant Mycoplasma pneumoniae, United States

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Xiaotian Zheng, Stella Lee, Rangaraj Selvarangan

    Emerging Infectious Diseases
    |July 22, 2015
    PubMed

    Insights

    Macrolide-resistant Mycoplasma pneumoniae (MRMP) is emerging in the US, with high-level resistance detected in over 13% of samples. This finding highlights the need for increased surveillance of this resistant bacterial strain.

    Area of Science:

    • Microbiology
    • Infectious Diseases
    • Antimicrobial Resistance

    Background:

    • Macrolide-resistant Mycoplasma pneumoniae (MRMP) is a growing global health concern, prevalent in Asia and increasingly reported in Europe.
    • Limited data exists on the prevalence and characteristics of MRMP within the United States.

    Purpose of the Study:

    • To investigate the prevalence of high-level macrolide resistance in Mycoplasma pneumoniae in the United States.
    • To characterize the resistance patterns of Mycoplasma pneumoniae strains in the US.

    Main Methods:

    • Genotypic methods were employed to detect resistance mechanisms.
    • Phenotypic methods were utilized to confirm macrolide resistance.
    • Analysis of 91 Mycoplasma pneumoniae-positive specimens from six diverse US locations.

    Main Results:

    • High-level macrolide resistance was detected in 13.2% of the analyzed Mycoplasma pneumoniae specimens.
    • The study identified MRMP in multiple geographic regions across the United States.
    • The prevalence indicates a significant presence of resistant strains in the US population.

    Conclusions:

    • Macrolide-resistant Mycoplasma pneumoniae is present at a significant level in the United States.
    • The findings underscore the urgent need for enhanced surveillance and diagnostic strategies for MRMP in the US.
    • This resistance poses a potential challenge for the effective treatment of Mycoplasma pneumoniae infections.
    Keywords:
    MICMycoplasma pneumoniaeUnited Statesantimicrobial resistancebacteriachildrenmacrolide

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