Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Propagation of Waves01:07

Propagation of Waves

3.4K
When a wave propagates from one medium to another, part of it may get reflected in the first medium, and part of it may get transmitted to the second medium. In such a case, the interface of the two mediums can be considered as a boundary that is neither fixed nor free.
Consider a scenario where a wave propagates from a string of low linear mass density to a string of high linear mass density. In such a case, the reflected wave is out of phase with respect to the incident wave, however the...
3.4K
Cell Migration01:19

Cell Migration

7.5K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.5K
Cell Migration01:09

Cell Migration

19.2K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.2K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.7K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.7K
Travelling Waves01:04

Travelling Waves

7.5K
A wave is a disturbance that propagates from its source, repeating itself periodically, and is typically associated with simple harmonic motion. Mechanical waves are governed by Newton's laws and require a medium to travel. A medium is a substance in which a mechanical wave propagates, and the medium produces an elastic restoring force when it is deformed.
Water waves, sound waves, and seismic waves are some examples of mechanical waves. For water waves, the wave propagation medium is...
7.5K
Elastic Strain Energy for Shearing Stresses01:20

Elastic Strain Energy for Shearing Stresses

623
As discussed in previous lessons, strain energy in a material is the energy stored when it is elastically deformed, a concept crucial in materials science and mechanical engineering. This energy results from the internal work done against the cohesive forces within the material. When a material undergoes shearing stress and corresponding shearing strain, the strain energy density, which is the energy stored per unit volume, is calculated. Within the elastic limit, where the stress is...
623

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.

Current biology : CB·2026
Same author

Active Solids: Topological Defect Self-Propulsion Without Flow.

Physical review letters·2026
Same author

Learning Epithelial Elasticity via Local Tension Remodeling.

bioRxiv : the preprint server for biology·2025
Same author

Gene expression cycles drive non-exponential bacterial growth.

Physical review research·2025
Same author

Reinforcement learning for adaptive control of phenotypically heterogeneous bacterial populations.

bioRxiv : the preprint server for biology·2025
Same author

Physical traits of supercompetitors in cell competition.

Journal of the Royal Society, Interface·2025

Related Experiment Video

Updated: Apr 6, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.8K

Propagating Stress Waves During Epithelial Expansion.

Shiladitya Banerjee1, Kazage J C Utuje2, M Cristina Marchetti2,3

  • 1James Franck Institute, The University of Chicago, Chicago, Illinois 60637, USA.

Physical Review Letters
|July 22, 2015
PubMed
Summary

This study models how cell monolayers expand during tissue repair and development. The model reveals how mechanical forces, cell polarization, and contractility interact to drive tissue dynamics and healing.

More Related Videos

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
08:41

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Published on: June 13, 2025

1.4K
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

6.0K

Related Experiment Videos

Last Updated: Apr 6, 2026

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
10:46

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

Published on: July 16, 2013

16.8K
Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy
08:41

Equibiaxial Stretching Device for High Magnification Live-Cell Confocal Fluorescence Microscopy

Published on: June 13, 2025

1.4K
Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

6.0K

Area of Science:

  • Biophysics
  • Cell Biology
  • Mechanobiology

Background:

  • Cellular coordination is crucial for tissue development and repair processes like epithelial wound healing.
  • Mechanical stress generation is a key factor in the coordinated motion of cell monolayers.
  • Understanding the interplay between mechanical forces and cellular behavior is essential for tissue morphogenesis.

Purpose of the Study:

  • To propose a novel model for epithelial expansion dynamics.
  • To couple mechanical deformations with cellular contractile activity and polarization.
  • To investigate the feedback mechanisms governing tissue mechanics and cell behavior.

Main Methods:

  • Development of a theoretical model integrating mechanical deformations, cell polarization, and contractility.
  • Incorporation of a feedback loop between local strain, polarization, and contractility.
  • Application of analytical and numerical techniques to study model dynamics.

Main Results:

  • The model naturally generates viscoelasticity and effective inertia in cell monolayers.
  • The model quantitatively reproduces experimental findings on intercellular stress buildup.
  • The model predicts the existence of traveling mechanical waves driving oscillatory monolayer expansion.

Conclusions:

  • The proposed model provides a framework for understanding epithelial expansion.
  • Feedback mechanisms between strain, polarization, and contractility are key to tissue dynamics.
  • The model elucidates the role of mechanical waves in guiding tissue morphogenesis and repair.