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Related Experiment Videos

Patient age and success in a human IVF programme.

K L Harrison1, T M Breen, J F Hennessey

  • 1Queensland Fertility Group, St Andrews Hospital, Brisbane.

The Australian & New Zealand Journal of Obstetrics & Gynaecology
|August 1, 1989
PubMed
Summary
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Pregnancy success via in vitro fertilization (IVF) remains viable up to age 40. After 40, IVF success rates significantly decline, with a marked increase in pregnancy loss, underscoring age as a critical factor.

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Maternal Age

Background:

  • Previous research indicates a decline in IVF pregnancy rates and an increase in pregnancy loss around age 40.
  • The precise age threshold for these changes remains unclear.

Purpose of the Study:

  • To delineate the specific age at which IVF success rates decline and pregnancy loss increases.
  • To evaluate IVF outcomes in women aged 41 and over.

Main Methods:

  • Retrospective analysis of 2,692 patients undergoing IVF.
  • Stratification of patient data by age, with a specific focus on women aged 41 and over (n=94).

Main Results:

  • Satisfactory pregnancy rates were observed up to and including age 40.

Related Experiment Videos

  • Pregnancy loss rates increased to approximately 40% as age 40 approached.
  • In women aged 41 and over, the pregnancy rate was 6% (6/94), with an 83% (5/6) pregnancy loss rate.

    • Conclusions:

    • IVF remains a viable option for achieving pregnancy up to age 40.
    • Significant decreases in IVF success and substantial increases in pregnancy loss occur after age 40.
    • Advanced maternal age (41+) is associated with poor IVF outcomes and high pregnancy loss rates.