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Patient age and success in a human IVF programme
K L Harrison1, T M Breen, J F Hennessey
1Queensland Fertility Group, St Andrews Hospital, Brisbane.
Summary
Pregnancy success via in vitro fertilization (IVF) remains viable up to age 40. After 40, IVF success rates significantly decline, with a marked increase in pregnancy loss, underscoring age as a critical factor.
Area of Science:
- Reproductive Medicine
- In Vitro Fertilization (IVF)
- Maternal Age
Background:
- Previous research indicates a decline in IVF pregnancy rates and an increase in pregnancy loss around age 40.
- The precise age threshold for these changes remains unclear.
Purpose of the Study:
- To delineate the specific age at which IVF success rates decline and pregnancy loss increases.
- To evaluate IVF outcomes in women aged 41 and over.
Main Methods:
- Retrospective analysis of 2,692 patients undergoing IVF.
- Stratification of patient data by age, with a specific focus on women aged 41 and over (n=94).
Main Results:
- Satisfactory pregnancy rates were observed up to and including age 40.
- Pregnancy loss rates increased to approximately 40% as age 40 approached.
- In women aged 41 and over, the pregnancy rate was 6% (6/94), with an 83% (5/6) pregnancy loss rate.
Conclusions:
- IVF remains a viable option for achieving pregnancy up to age 40.
- Significant decreases in IVF success and substantial increases in pregnancy loss occur after age 40.
- Advanced maternal age (41+) is associated with poor IVF outcomes and high pregnancy loss rates.