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Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
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Poly(ADP-ribosylation) and neurodegenerative disorders

Davide Alessandro Basello1, Anna Ivana Scovassi1

  • 1Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100 Pavia, Italy.

Mitochondrion
|July 22, 2015
PubMed

Insights

Impaired mitochondria are key in neurodegeneration. Poly(ADP-ribosylation) activation signals cell death, but inhibitors may offer therapeutic potential for these debilitating brain disorders.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biochemistry

Background:

  • Neurodegenerative disorders exhibit compromised mitochondrial structure and function.
  • Neural cell death in these conditions is triggered by unknown signaling pathways.
  • Poly(ADP-ribosylation) is a protein modification implicated in cell death signaling.

Purpose of the Study:

  • To describe the fundamental characteristics of poly(ADP-ribosylation).
  • To focus on the role of poly(ADP-ribosylation) in mitochondrial events.
  • To explore the potential of poly(ADP-ribosylation) inhibitors in neurodegenerative disease treatment.

Main Methods:

  • Review of existing literature on poly(ADP-ribosylation) and neurodegeneration.
  • Analysis of mitochondrial roles in cell death pathways.
  • Illustration of cell death paradigms including apoptosis, parthanatos, necroptosis, and mitophagy.

Main Results:

  • Poly(ADP-ribosylation) produces poly(ADP-ribose), a signaling molecule.
  • This process is linked to various cell death mechanisms.
  • Mitochondrial dysfunction is a central aspect of these pathways.

Conclusions:

  • Poly(ADP-ribosylation) plays a significant role in neurodegenerative processes.
  • Targeting poly(ADP-ribosylation) with inhibitors presents a promising therapeutic strategy.
  • Further research into poly(ADP-ribosylation) inhibitors could lead to novel treatments for neurodegeneration.
Keywords:
ApoptosisMitochondriaMitophagyNeurodegenerationParthanatosPoly(ADP-ribosylation)

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