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Updated: Apr 6, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Invasive assessment of the coronary microcirculation in the catheter laboratory
Jamie Layland1, Nitesh Nerlekar2, Sonny Palmer3
1West of Scotland Heart and Lung Centre, Golden Jubilee Hospital, Clydebank, Scotland, United Kingdom; BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom; Department of Cardiology St Vincent's Hospital, Fitzroy, Victoria, Australia; Department of Cardiology, Peninsula Health, Frankston, Victoria, Australia.
Insights
Understanding coronary microcirculation is crucial for patient outcomes. This review covers its physiology and invasive measurement techniques used in the catheter laboratory.
Area of Science:
- Cardiovascular physiology
- Medical technology
Background:
- Historically, focus on epicardial coronary vessels overshadowed the microcirculation.
- Emerging evidence underscores the coronary microcirculation's impact on patient outcomes in various clinical conditions.
Purpose of the Study:
- To review the physiology of the coronary microcirculation.
- To evaluate invasive techniques for assessing microvascular function in the catheter laboratory.
Main Methods:
- Literature review of invasive methods for coronary microcirculation assessment.
- Discussion of the physiological principles governing coronary microvascular function.
Main Results:
- Coronary microcirculation plays a vital role in cardiovascular health.
- Invasive techniques offer valuable tools for interrogating microvascular function.
Conclusions:
- Accurate assessment of coronary microcirculation is essential for clinical practice.
- Further understanding and application of invasive techniques can improve patient care.
Abstract:
Historically much of our understanding of the coronary circulation has been centered towards the epicardial vessels. However, recent work has highlighted the importance of the coronary microcirculation across a broad spectrum of clinical conditions in influencing patient outcomes. Therefore an ability to measure microvascular function is most valuable. While evaluation of the epicardial coronary circulation is widely understood, interrogation of the coronary microcirculation is more complex. Many methods are available to assess the integrity of the microcirculation in the catheter laboratory. This review will discuss the physiology of the coronary microcirculation and evaluate the utility of available invasive techniques.
Related Concept Videos
Acute Coronary Syndrome III: Diagnostic Studies
Cardiac Catheterization I: Pre-Procedure Overview
Cardiac Catheterization III: Left Heart Catheterization
Cardiac Catheterization II: Right Heart Catheterization

