Sixteen weeks of resistance training decrease plasma heat shock protein 72 (eHSP72) and increase muscle mass without
K Perreault1,2, A Courchesne-Loyer2,3, M Fortier2
1Faculté des sciences de l'activité physique, Université de Sherbrooke, Sherbrooke, QC, Canada.
Aging Clinical and Experimental Research
|July 23, 2015
Summary
Extracellular heat shock protein 72 (eHSP72) levels decreased after resistance training in sarcopenic men, showing concordance with increased lean body mass. However, low detection rates may limit its clinical use for sarcopenia.
Area of Science:
- Gerontology
- Exercise Physiology
- Biomarker Research
Background:
- Sarcopenia is linked to inflammation and physical disability in older adults.
- Extracellular heat shock protein 72 (eHSP72) is a proposed sarcopenia biomarker.
- eHSP72's response to muscle-building interventions is unstudied.
Purpose of the Study:
- Assess eHSP72 levels after resistance training.
- Correlate eHSP72 changes with muscle mass and inflammation markers.
Main Methods:
- 26 sarcopenic men underwent a 16-week resistance training program.
- Measured plasma eHSP72, inflammatory markers (hsIL-6, hsCRP, hsTNF-α), and lean body mass (LBM) pre- and post-intervention.
Main Results:
- eHSP72 decreased significantly (P=0.04) post-training.
- Lean body mass and appendicular muscle mass index increased (P<0.035).
- No significant changes in inflammatory markers; baseline hsIL-6 correlated with LBM changes.
Conclusions:
- eHSP72 decrease aligns with LBM gains, suggesting biomarker relevance in sarcopenia.
- Low eHSP72 detection rates in sarcopenic individuals may limit current clinical application.
