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Application of an analytical method to calcium acetylhomotaurinate determination in urine
C Chabenat1, P Ladure, N Moore
1Laboratoire de Pharmacochimie, Unité d'Enseignement et de Recherche de Médecine Pharmacie de Rouen, Saint-Etienne-du-Rouvray, France.
Arzneimittel-Forschung
|November 1, 1989
Abstract:
After urine purification, plasma and urine concentrations of calcium acetylhomotaurinate (Acamprosate, CaAOTA) were determined with a high-performance liquid chromatography method following i.v. administration of the drug in two dogs. Results obtained in serum were in good agreement with those found previously. The CaAOTA urine determination is a promising method to be used in healthy volunteers.