A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496
Minghe Luo1,2, Guiling Tang2, Jianhua Ju2
1a Department of Pharmacy , Institute of Surgery Research, Daping Hospital, Third Military Medical University , Chongqing 400042 , P.R. China.
Abstract:
A new diketopiperazine (DKP) derivative, (6R,3Z)-3-benzylidene-6-isobutyl-1-methyl piperazine-2,5-dione (1), as well as five known DKPs 2-6 was isolated from a deep sea-derived Streptomyces sp. SCSIO 04496. The structure of 1 was elucidated using a combination of 1D and 2D NMR, HR-ESI-MS and chiral-phase HPLC techniques. Compounds 1-6 did not show cytotoxic activity at a concentration of 100 μM in bioactivity assay.
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